Swiss researchers identify gene variants linked to cancer progression
ETH researchers investigate cancer mutations in the genome
Keystone-SDA
Select your language
Generated with artificial intelligence.
Listening: Swiss researchers identify gene variants linked to cancer progression
Researchers at the federal technology institute ETH Zurich have investigated how genetic mutations impact cell function. By employing two CRISPR/Cas techniques, they assessed the importance of these mutations in cancer development and treatment.
This content was published on
2 minutes
Keystone-SDA
Deutsch
de
ETH-Forschende untersuchen Krebs-Mutationen im Erbgut
Original
Researchers at the Department of Biosystems Science and Engineering at ETH Zurich in Basel modified a gene in two human cell lines in over 50,000 different ways.
This allowed them to create a vast array of cell variants, which they then tested for functionality. They focused on a gene crucial to the development of various types of cancer, including lung, brain and breast cancer.
More
More
Swiss cancer research could ‘boost’ immunotherapy
This content was published on
Swiss researchers have made major advances in cancer immunotherapy but bringing these to patients faces challenges.
To generate such a vast number of gene variants, the researchers combined two CRISPR/Cas methods, ETH Zurich announced on Tuesday. Base editing allows for easy and reliable modification of individual DNA building blocks, while prime editing enables precise alterations to specific gene segments.
According to ETH Zurich, the researchers identified and described the significance of ten gene variants that previously had an unclear impact on cancer development.
These variants either contribute to cancer progression or make it resistant to certain drugs. The research team also discovered a new mechanism by which a mutation in the investigated gene can cause cancer and identified six new, relevant gene variants involved in cancer.
Cell pools with different gene variants are crucial for research. Oncologists are increasingly examining the genetic information of patients’ tumour cells. This data offers insights into which drugs might be effective for each individual patient, the report continued.
Translated from German by DeepL/sp
This news story has been written and carefully fact-checked by an external editorial team. At SWI swissinfo.ch we select the most relevant news for an international audience and use automatic translation tools such as DeepL to translate it into English. Providing you with automatically translated news gives us the time to write more in-depth articles.
If you want to know more about how we work, have a look here, if you want to learn more about how we use technology, click here, and if you have feedback on this news story please write to english@swissinfo.ch.
Popular Stories
More
Culture
Documentary portrays Swiss teenagers forced to return to parents’ homeland
French cross-border workers in Switzerland fear “discriminatory” unemployment reform
This content was published on
In the French region around Geneva, cross-border workers are protesting proposals to cut unemployment benefits for those working in Switzerland.
Swan infected with bird flu in central Switzerland
This content was published on
Switzerland has reported its first bird flu case of the season. A swan found dead in central Switzerland tested positive for the H5N1 virus.
Explosion at Swiss company Givaudan’s US plant leaves two dead
This content was published on
Swiss flavour and fragrance maker Givaudan reported that an explosion at its Kentucky plant resulted in two deaths and several injuries.
Swisscom’s Vodafone Italia takeover cleared by Italian telecoms authority
This content was published on
Swisscom is one step closer to its planned acquisition of Vodafone Italia, as the Italian communications regulator has approved the €8 billion deal.
Swiss parliamentary committee proposes foreign aid cuts and military funding boost
This content was published on
A committee of the Swiss House of Representatives has proposed increasing funds for the military and agriculture while reducing foreign aid and asylum.
Swiss Rolex Submariner watches reach nearly $50 billion in total market value
This content was published on
The total market value of all Rolex Submariner watches ever made is nearly $50 billion, based on newly released production data.
Swiss Jew wrongfully detained due to prosecutor’s ‘bias’
This content was published on
A Jewish Swiss man was detained after the prosecutor argued he might flee to Israel. The Federal Court said this implies bias due to his Jewish faith.
US reportedly scrutinises Russian accounts UBS took over from Credit Suisse
This content was published on
The US is investigating Russian clients acquired by UBS during its takeover of Credit Suisse, according to three sources familiar with the matter.
WTO plans to reappoint Okonjo-Iweala before Trump swears in
This content was published on
Some member states of the World Trade Organization may seek to reappoint Director-General Ngozi Okonjo-Iweala, according to a document released on Tuesday.
Swiss village gets half a million amid rockfall threat as some residents resist evacuation
This content was published on
The Swiss village of Brienz has been granted CHF500,000 due to a rockfall threat. But some residents are questioning the authorities’ evacuation orders.
You can find an overview of ongoing debates with our journalists here . Please join us!
If you want to start a conversation about a topic raised in this article or want to report factual errors, email us at english@swissinfo.ch.